Since today's patch we can't use the mouse scroll wheel while holding the left click to move items. It tries to discard the item. To reproduce, make your inventory small enough that you need to scroll to access the bottom bag. Click and hold something in bag 1, scroll to view the last bag. Before you get to the bottom it will drop your item and try to discard it.
I thought my mouse was on the way out until I had others try while in discord and it happens to them as well. You can scroll a small bit but not enough to reach the bottom bag.
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As a workaround or replacement, I found recently that you can drag items onto the little bag icons at the bottom of the inventory pane and it transfers the item to the respective bag assuming there is space. If you drag the item to the side icon, it moves it to the first available space, exactly as if you'd just picked the item up. Makes rearranging stuff in a lot of bags much easier.