I think for a paladin, this is one of more insanely overpowered WEs available. I've tested (non-ACT) other enchantments, but nothing really seems to melt mobs faster than a good old (trans) Plaguefire. Between the debuff and DoT, it makes solo content supremely easy and group content really sped up since all party members benefit from it. What's more: it is probably the cheapest WE at Transcendent in the AH.
I can see for a ProtOP you might want a Dread since you are focusing on crit for TW, but as a DevOP, the constant damage output and debuff from PF seems hard to beat.
What do you folks run, and why?