Did more tests and here's what I found. The bug seems to trigger the most when firing your weapons with, as noted by others, a weapon enhancement ability active (in my case, Beam Overload), but that's incomplete. The bug really loves to trigger when you do that AND continue to fire right as the weapon enhancement ability…
I'd also like to add that Reputation weapons are also very much affected, at least when it comes to the Radiant Antiproton Beam Arrays (Iconian Rep) that I use.
Several threads about this issue have already been created in the bug report sub-forum, with this one being the most prominent and informative: https://www.arcgames.com/en/forums/startrekonline#/discussion/1261966/weapons-wont-fire Looking through that thread, it appears that Cryptic is aware of the issue and I hope it…