After having a series of problems with trying to get into the game from the launcher (the black screen that can't load in the Cryptic, with the swirling busy cursor), I've had to use the Safe Mode option to proceed past this blank black screen.
The only time that I know of where you have the option to optimize the game without an external program (such as NVidia's GeoForce Experience, if that was allowed to be able to optimize it) is to effectively redownload the game. Because the only time is when you first launch the game after download.
Of course, this could be avoided if the game had an optimization button available in-game. This way if players had to go to Safe Mode, or they bought a new graphics card and/or monitor/TV for their computer, they can easily be able to get their game back up to speed graphics-wise without manually fiddling with all of the settings to get it back to the optimized settings.