Yes they do. If say your resistance ignored brings the enemie's dmg resistance % from the defense stat+AC to 0(it cant take it into negative and affect tenacity alone) the 45% debuf from greater plague fire will affect tenacity. So if your enemy has 20% DR from tenacity your attack would do its full dmg + 25% bonus dmg. On a critical hit the 20% DR from tenacity's crit.strike resistance comes into play and in this case you would get a 5% dmg bonus.
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