As of today I encountered a chest bug in ME runs.
a. got normally the quest.
b. collected all needed runes.
c. no chest loot, i was able to interact with it but it was not opening (no loot pop-up)
This happened 3 times in a row.
Ogguk The Beholder… Justicar Paladin Tank/ Healer
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This was in the patch notes and seems relevant. Not sure exactly what it means, especially for players who already did it.
I don't think it has anything to do with runic resonator because it started a couple weeks ago before Mod 17 for me.
I've reported it several times in game.
EDIT: It was the runic resonator. Picking back up the artifact gear quest gave me a new one. I originally dropped the mission because I wasn't going to grind for essence and I didn't want to see it in my journal.
Why the resonator was removed from my inventory in the first place I can't say, it's not something that goes in a backpack so I didn't even know I had it in the first place.