recent patch on Star Trek has messed up compatibility with Win 10, see also Graphical and technical known issues - Catalyst Driver and STO crashed Yet to see a response from anyone with actual answers
Same issue, sometimes it works other times it does not, usually you have to Force Verify, but there is no guarantee that will work either, seems no one is offering any real solutions, I cannot even open it in Safe Mode, damn thing wont let me.
Its to do with Win10 and the incompatibility of recent patches between the 10th and 13th of August, same on Star Trek, having issues with the recent Catalyst Display see "Catalyst Driver and STO crashed"