Last night around 10 PM central I started having the same issue (opening doors, interacting with NPCs, etc) on 1 character. After the DDoS, in Blackdagger Ruins (not Drowned Shore), went to enter the Sea Caves (Old Lenn - I think that is the NPC's name - quest), went to door, clicked to enter, game crashed, got a message (I had never seen before) "could not find/load (?) character container" (or something similar to that, should have written it down), logged back in on same character, same issue, Moonstone Mask teleport would not work, basically stuck in Blackdagger Ruins, could still attack/kill mobs, could not interact with anything else.
Logged on to a couple other characters & did not experience any issues.
Seems like I am not alone, zone chat (Blackdagger ruins) last night, reddit, and these forums all describing something similar.
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Temporary solution to get out of it is leave your character online for 15 minutes and you will get logged out properly due to inactivity. When you log back in, you will be able to interact. Do not try to enter an instance or perform the same action that bugged your character, because it will happen again, and your character will get stuck again. Just move along, do something else, in my case I just moved on to drowning shores seems stable, in order to be able to do any quests.
I went back to finish this quest in whispering caverns(my bugged zone) entering ilithid cave or something every day for 3 days and still bugs.
I've also noticed yesterday guild siege tutorial zone is bugged for me.
In any case, I can't find a single response from support staff about this bug, but I'm very sure they're aware of it, since i've seen so many people complain about it.
I don't believe a bug of this magnitude will get left alone for very long, and I don't believe they have a solution yet, otherwise we would have heard something.
So fingers crossed they will have a patch for this soon.