As the question states I have been curious on this subject of late now that all four quadrants are available for the most part. I would like to give some suggestions such as a possible idea on investigating the galactic and great barriers, maybe including the Kelvans as well as the false "god" entity on Sha Ka Ree, with possible new ships like the SS Valiant type popping up. Or looking into the machine race that turned Voyager VI into V'Ger, maybe have a connection to the makers of the whale probe. Many mysteries yet to consider now with perhaps one involving the Romulan War which while I feel it might be a good way to include more Enterprise era ships, such as the Warp Delta type, SS Emmette, even maybe single episode ships like the Wisp ship, I am unsure how it could be integrated without resorting to another time travel plot line. Anyway, like I said I am simply curious where things could lead now as well as extending that curiosity to what others may think could now occur.