You need to go to Memory Alpha in Alpha Centauri Sector. As for guides, good luck with that. They really need to overhaul that mechanic.
To Start Crafting you must accept a mission from Admiral Quinn called "scientific Mandate" then you must find an NPC called E'Genn who can be found in the middle of Sol Starbase. He gives you a sample to take to Romaine at Memory Alpha. Talk to Romaine and she asks you to put the sample in a flashing console which is near her, do this, then speak to her again. the mission should now complete and you can upgrade certain stuff from her with the data samples you have collected.
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To Start Crafting you must accept a mission from Admiral Quinn called "scientific Mandate" then you must find an NPC called E'Genn who can be found in the middle of Sol Starbase. He gives you a sample to take to Romaine at Memory Alpha. Talk to Romaine and she asks you to put the sample in a flashing console which is near her, do this, then speak to her again. the mission should now complete and you can upgrade certain stuff from her with the data samples you have collected.