In principle I think so, there are those 12 button MMO gaming mice that could with a little key binding give a fair degree of control, with a lot a key binding including automated cycling of buffs it might be pretty good and better than some people that click each ability as they need it. Ideally two handed play of some kind would be best, even if it were a single finger to press shift, control or neither.
An endgame ship has at least 3 rows of abilities, plus weapons, steering, target selection, chat, for all players its a handful so figuring ways to simplify the input has been done with keybinding files that can be edited by the user. The big users of these are PVP players, I believe they use http://www.ifes.us/STOKeyBind/ from http://hilbertguide.com/
Whatever specific tools they go for I'm sure they'd be happy to help.
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An endgame ship has at least 3 rows of abilities, plus weapons, steering, target selection, chat, for all players its a handful so figuring ways to simplify the input has been done with keybinding files that can be edited by the user. The big users of these are PVP players, I believe they use http://www.ifes.us/STOKeyBind/ from http://hilbertguide.com/
Whatever specific tools they go for I'm sure they'd be happy to help.
there you go mate i hope this helps, its done by an old friend and i think its closer to what you might want
Solo STF's With Optional ISE: 3:34
i have all logs saved of these so if you would like to view them send me a pm and it can be arranged