Take a look at this NASA collaboration video:
http://www.youtube.com/watch?feature=player_embedded&v=lxI1L1RiSJQ
There are some pretty nifty in-game recordings towards the end, after the science experiment on the ISS. Simplified orbital mechanics will be prominently featured, which means wierd orientations and slingshot maneuvers... and of course, de-orbiting evil green pigs with strategic pillow interceptors!