I received the death sphere curse so that I could help my party complete the first boss in TONG. However, the temp hit points AND the inability to take damage remained with my character for the whole dungeon. I could not die and I was not taking any damage from any mob or boss. The 'curse' did not clear until I left the dungeon.
LEVIATHAN--19.3k Metallic Dragonborn Guardian Fighter Swordmaster Loadouts
Guild--And the Imaginary Friends
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So it either applies (and sometimes applies for the whole dungeon - it still runs out, and will go if you wipe), or doesn't apply at all.
Guild--And the Imaginary Friends