It sounds like a very interesting build and should work for you. I've already maxed out the mastery on two of my main Captains. One is using the plasma set and most of the stuff from her Chronos dreadnought and it still mows down things.
My other is using Tetryon and had been using the Nukara rep ship set, but swapped it for the Preeminent set.
Yours sounds pretty awesome, actually.